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Our look at trends in drug discovery, materials science, and how they interact with computation.

Intramolecular Hydrogen Bonds for Brain-Penetrant IP6K1 Inhibitors

Adding intramolecular hydrogen-bond acceptors can help otherwise recalcitrant drugs make it past the blood–brain barrier.
Aug 6, 2024
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Corin Wagen
Intramolecular Hydrogen Bonds for Brain-Penetrant IP6K1 Inhibitors